Abstract: Metformin & MNT are used from 8 to 10 weeks of pregnancy to prevent gestational diabetes. According to Dr. Seshiah, significant changes occur in maternal metabolism when fetal insulin secretion begins. Hyperglycemia can lead to non-communicable diseases later in life, which is why gestational diabetes is often referred to as a precursor to these conditions. It is important to avoid the transgenerational transmission of diabetes. Spot Test was discovered by the V Seshiah group 40 years ago, with 105 mg/dl by plasma lab value and 110 mg/dl by plasma calibrated Glucometer, which are equal values.