{"id":2011,"date":"2026-03-28T06:36:51","date_gmt":"2026-03-28T06:36:51","guid":{"rendered":"https:\/\/diabetesasia.org\/journal\/?p=2011"},"modified":"2026-03-28T07:25:44","modified_gmt":"2026-03-28T07:25:44","slug":"primary-neonatal-outcomes-in-metformin-and-mnt-group-in-early-trimester-with-early-gestationalglucose-intolerance","status":"publish","type":"post","link":"https:\/\/diabetesasia.org\/journal\/primary-neonatal-outcomes-in-metformin-and-mnt-group-in-early-trimester-with-early-gestationalglucose-intolerance\/","title":{"rendered":"Primary Neonatal Outcomes in metformin and MNT group in Early Trimester with Early GestationalGlucose Intolerance"},"content":{"rendered":"\n<h1 class=\"wp-block-heading\">Primary Neonatal Outcomes in metformin and MNT g<\/h1>\n\n\n\n<p>S. Agarwal1, S. Tiwari1, S. Verma1, P. Taneja1, S. Veeraswamy2, R. Jain3, P. Saxena4, A. Chandrasekar5, B.Natarajan6.1GSVM Medical College, Obstetrics and Gynaecology, Kanpur, India. 2The MGR Tamilnadu Medical University, Obstetrics and Gynaecology, Chennai, India. 3 Jain Hospital &amp; Research Centre Pvt Ltd, Medicine, Kanpur, India. 4 LHMC Medical College, Obstetrics and Gynaecology, New Delhi, India. 5 Madha Medical College and Research Institute, Obstetrics &amp; Gynaecology, Chennai, India.6 SRC Diabetes Centre-, Diabetes, Erode, India<\/p>\n\n\n\n<p>Abstract<\/p>\n\n\n\n<p>Method<br>A study included pregnant women at 8 to 10 weeks of gestation, divided into two groups based on their blood sugar levels of\u2265110 mg\/dl. Those with high levels \u2265110 mg\/dl received two different interventions: Metformin-MNT and MNT only. Follow-up outcomes were done until delivery.<br>Results<br>Primary Outcomes* The Adverse neonatal composite outcomes in the groups were 35 (37.6%) vs 55 (52.3), which were statistically significant (P = 0.038), but the Primary Maternal hypertension composite outcomes were not significant (9 (9.6%) vs 10 (10.7%), P = 0.80) (Table 1). IUD\/Spontaneous abortion 8-28 Weeks and stillbirth are 20 (16) and 12(9.6) in the MNT Group compared to nil in the MNT-Metformin intervention group, which is highly significant.<br>Conclusion: It&#8217;s important to keep maternal 2-hour postprandial blood glucose (PPBG) levels below 110 mg\/dL in the 10th week of pregnancy to prevent fetal hyperinsulinemia and improve maternal-fetal health.<\/p>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/diabetesasia.org\/journal\/wp-content\/uploads\/2026\/03\/Poster-3.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Embed of Poster 3.\"><\/object><a id=\"wp-block-file--media-4ff080e6-5710-420c-9026-fb802a758dd4\" href=\"https:\/\/diabetesasia.org\/journal\/wp-content\/uploads\/2026\/03\/Poster-3.pdf\">Poster 3<\/a><a href=\"https:\/\/diabetesasia.org\/journal\/wp-content\/uploads\/2026\/03\/Poster-3.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-4ff080e6-5710-420c-9026-fb802a758dd4\">Download<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Primary Neonatal Outcomes in metformin and MNT g S. Agarwal1, S. Tiwari1, S. Verma1, P. Taneja1, S. Veeraswamy2, R. Jain3, P. Saxena4, A. Chandrasekar5, B.Natarajan6.1GSVM Medical College, Obstetrics and Gynaecology, Kanpur, India. 2The MGR Tamilnadu Medical University, Obstetrics and Gynaecology, Chennai, India. 3 Jain Hospital &amp; Research Centre Pvt Ltd, Medicine, Kanpur, India. 4 LHMC Medical College, Obstetrics and Gynaecology, New Delhi, India. 5 Madha Medical College and Research Institute, Obstetrics &amp; Gynaecology, Chennai, India.6 SRC Diabetes Centre-, Diabetes, Erode, India Abstract MethodA study included pregnant women at 8 to 10 weeks of gestation, divided into two groups based on their blood sugar levels of\u2265110 mg\/dl. Those with high levels \u2265110 mg\/dl received two different interventions: Metformin-MNT and MNT only. Follow-up outcomes were done until delivery.ResultsPrimary Outcomes* The Adverse neonatal composite outcomes in the groups were 35 (37.6%) vs 55 (52.3), which were statistically significant (P = 0.038), but the Primary Maternal hypertension composite outcomes were not significant (9 (9.6%) vs 10 (10.7%), P = 0.80) (Table 1). IUD\/Spontaneous abortion 8-28 Weeks and stillbirth are 20 (16) and 12(9.6) in the MNT Group compared to nil in the MNT-Metformin intervention group, which is highly significant.Conclusion: It&#8217;s important to keep maternal 2-hour postprandial blood glucose (PPBG) levels below 110 mg\/dL in the 10th week of pregnancy to prevent fetal hyperinsulinemia and improve maternal-fetal health.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2011","post","type-post","status-publish","format-standard","hentry","category-blog"],"_links":{"self":[{"href":"https:\/\/diabetesasia.org\/journal\/wp-json\/wp\/v2\/posts\/2011","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/diabetesasia.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/diabetesasia.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/diabetesasia.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/diabetesasia.org\/journal\/wp-json\/wp\/v2\/comments?post=2011"}],"version-history":[{"count":2,"href":"https:\/\/diabetesasia.org\/journal\/wp-json\/wp\/v2\/posts\/2011\/revisions"}],"predecessor-version":[{"id":2023,"href":"https:\/\/diabetesasia.org\/journal\/wp-json\/wp\/v2\/posts\/2011\/revisions\/2023"}],"wp:attachment":[{"href":"https:\/\/diabetesasia.org\/journal\/wp-json\/wp\/v2\/media?parent=2011"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/diabetesasia.org\/journal\/wp-json\/wp\/v2\/categories?post=2011"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/diabetesasia.org\/journal\/wp-json\/wp\/v2\/tags?post=2011"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}